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Scientist - Cell-Based Assay Development & Execution - Thousand Oaks California
Company: Amgen Inc. (IR)
Location: Thousand Oaks, California
Posted On: 11/12/2024
Scientist - Cell-Based Assay Development & ExecutionCareer Category: ScientificJob DescriptionHOW MIGHT YOU DEFY IMAGINATION?You've worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.Scientist - Cell-based Assay Development & ExecutionWhat you will doIn this vital role, you will be a part of the Therapeutic Discovery organization joining the Lead Discovery and Characterization Department in support of Amgen's small molecule drug discovery pipeline. - The development and optimization of novel cell-based assays to ensure successful implementation and routine execution of these assays to support HTS, lead optimization, and mechanism-of-action studies for promising therapeutic targets.
- Design and implement laboratory experiments, generate & interpret data supporting the successful development of new assays and test the biological effects of therapeutic agents.
- Design, implement, and optimize gene-editing workflows in a manner that enables development and evaluation of cell-based functional assays supporting therapeutic target screening or lead optimization studies.
- Learn, apply, and incorporate automation solutions during assay development, assay troubleshooting, mechanism-of-action studies, data analysis, and reporting.
- Investigate, identify, develop, and optimize new methods/techniques to generate reliable and reproducible data promptly.
- Semi-independently plan and implement experiments, adapt readily to changing project needs and develop sophisticated problem-identification and problem resolution skills.
- Maintain proficiency with the latest scientific literature and rationale surrounding drug targets and be an active contributor to the interpretation of results in group discussions.
- Show excellent collaboration and communication skills as this role requires an ability to work closely with other scientists in the group and across Amgen.
- Adhere to good laboratory conduct, documentation practices, and safety guidelines.What we expect of youThe dynamic professional we seek is a scientist with these qualifications.Basic Qualifications:
- Master's degree and 2 years relevant experience.Or
- Bachelor's degree and 4 years of relevant experience.Preferred Qualifications:
- Ph.D. degree with 1+ years of post-doctoral training or a master's degree with 5+ years postgraduate experience in cell and/or molecular biology or closely related field.
- Experience working as part of a multi-disciplinary team in a biopharmaceutical setting.
- Strong scientific foundation in the understanding and implementation of a wide range of cell-based assays (e.g., TR-FRET, BRET, AlphaLISA, HCS, luminescence and fluorescence-based reporter and/or label-free assays) with experience in the utilization of lab automation across assay development and screening.
- Track record of developing, implementing, and performing novel cell-based screening assays in microtiter plates to support early drug discovery research.
- Ability to design and implement gene editing (CRISPR knock out/in) workflows enabling the development of targets specific and disease-relevant cell-based assays.
- Capacity to identify, evaluate, implement, and become proficient in novel laboratory techniques.
- Ability to create and establish priorities, manage work plans, and meet timelines.
- A flexible approach with strong interpersonal, communication and problem-solving skills.
- Demonstrated initiative, teamwork, collaboration, and passion for developing technical expertise across assay development to routine execution.
- Familiarity with software and statistical platforms for the analysis of large data sets (e.g., Screener, Spotfire).What you can expect of usAs we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
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