Principal Scientist, Purification Development - Indianapolis Indiana

Company: Eli Lilly and Company
Location: Indianapolis, Indiana
Posted On: 11/13/2024

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.Organization overview:The Bioproduct Research and Development organization strives to deliver creative medicines to patients through the development and commercialization of insulins, monoclonal antibodies, novel therapeutic proteins, peptides, oligonucleotide therapies and gene therapy systems. This organization is a multidisciplinary group that works collaboratively with our discovery and manufacturing colleagues. Located in Indianapolis, scientists have full access to our scientific excellence and engineering capabilities.Do you enjoy downstream drug substance processes including purification and filtration of monoclonal antibodies, recombinant proteins, viral vectors, or peptides? Do you have experience with process development and tech transfer? Are you skilled in the analytical techniques used to characterize bioproducts? If so, then a role as a Purification Development Scientist is waiting for you.Responsibilities:

• Work to design efficient and effective downstream drug substance processes for new biologic candidates, as they make their way from discovery to the clinic and commercial application.
• The ability to troubleshoot issues as they occur, and to identify trends and opportunities to reduce process variability, are also key.
• The ability to exhibit a high level of attention to detail and a quality-minded approach to all record keeping, especially electronic notebook, is essential.
• Maintaining accurate records and interpreting data to provide detailed information and analysis on the execution of experiments will be a daily activity.
• Writing technical reports and tech transfer documents to summarize development activities is an important deliverable.
• Effective interaction and communication of technical information with, but not limited to Safety, Environmental and Quality Team members, Purification Development colleagues, CMC Team members, Discovery team members, Analytical Services, Tech Service/Manufacturing Science representatives, Operations, Engineering, and Maintenance personnel.
• Adhere to all safety and environmental guidelines and promote a proactive safety culture and environmental compliance in all areas.Basic Qualifications/ Requirements:
  • BS/MS in Chemistry, Biochemistry, Chemical Engineering or related degree
  • > 3 years of experience relevant to protein purification/process developmentAdditional Skills/Preferences:
    • Process development experience with extensive knowledge in chromatography and filtration (TFF, NFF, etc.).
    • Experience with process control and documentation systems (UNICORN control software, electronic notebooks)
    • Effective oral and written communication skills.
    • Strong laboratory skills
    • Ability to interact and form dynamic relationships with a wide range of groups
    • General interpersonal and communication skills; mentoring, feedback, training, and cultivating an environment for learning and open/honest communication
    • Basic analytical and problem-solving skills
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