Abiologics, Inc - Boston, MA Senior Scientist, Discovery - Boston Massachusetts

Company: Flagship Pioneering
Location: Boston, Massachusetts
Posted On: 11/21/2024

Company Overview: Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through chemistry. We are pioneering the development of Synteins TM, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional molecular scientists who are passionate about driving chemical innovation in biotechnology.Abiologics was founded in Flagship Pioneering's venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship's founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.Position Summary: We are looking for a highly motivated, experienced cell biologist and assay development/screening scientist to join our growing team. In this role, the successful candidate will be responsible for developing and executing novel cell-based screening assays to drive the Abiologics Syntein TM discovery platform. This is a hands-on, lab-based role and will serve as the cell biology lead/expert within the Discovery team. In addition, this role will collaborate cross-functionally with a diverse design-make-test team across Abiologics and have the opportunity to impact platform and company build-out.Key Responsibilities:

• Design, develop and execute cell-based screening assays to assess Syntein TM activity, target engagement and mechanism of action to drive discovery programs.
• Lead cell biology efforts within the Discovery team to identify and implement relevant cell-based assays for diverse target classes and disease areas (immunology, oncology, metabolism).
• Collaborate within the Discovery team on biochemistry and biophysics projects and provide cell biology expertise and guidance to junior team members.
• Collaborate cross-functionally to enable novel methods, assays and screening workflows.
• Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry teams to drive design-make-test cycles.
• Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings.Qualifications:
  • PhD in molecular or cell biology or related discipline with minimum 3 years relevant experience in industry required.
  • Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, and reporter cell lines.
  • Proficient in industry-standard cell-based assay and bioanalytical techniques including TR-FRET, ELISA, flow cytometry, and reporter gene; experience with cellular/high content imaging and image analysis a plus.
  • Experienced with primary cell culture and characterization, including tissue dissociation and cell isolation of various immune cell types.
  • Demonstrated ability to independently design, develop and optimize diverse cell-based assays and interpret complex results.
  • Disease biology expertise in immunology or oncology highly desired.
  • Proficiency in laboratory automation and semi-automated screening workflows a plus.
  • Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality.Equal Employment Opportunity: Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.Application Note: At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
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