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Senior Cell Biologist/Tissue Bioengineer - Cambridge Massachusetts
Company: Draper Labs Location: Cambridge, Massachusetts
Posted On: 01/15/2025
Overview:Draper is an independent, nonprofit research and development company headquartered in Cambridge, MA. The 2,000+ employees of Draper tackle important national challenges with a promise of delivering successful and usable solutions. From military defense and space exploration to biomedical engineering, lives often depend on the solutions we provide. Our multidisciplinary teams of engineers and scientists work in a collaborative environment that inspires the cross-fertilization of ideas necessary for true innovation. For more information about Draper, visit .Job Description Summary:The Bioengineer (SMTS) is focused on developing and deploying multidisciplinary solutions at the convergence of biology and engineering to address critical needs in national security and healthcare while fostering a thriving culture and developing the next generation of innovators. The Bioengineer will apply their foundational knowledge and experience to a broad range of interdisciplinary efforts. Our culture fosters innovation, a supportive team environment, intellectual freedom and creativity, and an emphasis on career development. Duties are performed with limited supervision.Job Description:Duties/Responsibilities * Drive solutions to complex problems with limited direction. * Contribute to the development of innovative bioengineering solutions, propose ways forward, and adapt appropriately to changes in requirements. * Able to provide insight and suggest design modifications based on analysis outcomes. * Actively mentor less experienced bioengineers and provide thoughtful, constructive feedback. * Performs other duties as assigned. Skills/Abilities * Strong foundation in biology and/or engineering principles. * Team player, dedicated, collaborative, observant, and motivated. * Excellent organizational skills, attention to detail, and verbal and written communication skills. * Creative problem-solving skills and a passion for innovation. * Excellent time management skills with the proven ability to meet deadlines and prioritize tasks. * Enthusiasm for learning and participating in mentorship/mentoring. * Proficiency with Microsoft Office Applications. Education Requires either a Bachelor's Degree in Bioengineering, Biomedical Engineering, Biochemistry, Chemistry, Cell Biology, Immunology, Microbiology, Molecular Biology, Mechanical Engineering, Chemical Engineering, Physics or related fields. Master's degree preferred. Experience Requires 5-7 years of Bioengineering or related engineering experience. Additional Job Description:The Bioengineering Division is seeking an experienced Senior Scientist to support the research and development of cutting-edge technologies. At Draper Bioengineering, we work at the interface between engineering and biology, and the successful applicant will join teams working on microphysiologic systems (organ-on-chip), along with other capabilities in development.The successful candidate will be enthusiastic, observant, collaborative, and dedicated, and will serve as a subject matter expert, applying their foundational immunology knowledge and experience to exciting, interdisciplinary efforts. Draper offers a distinctive atmosphere that blends the best aspects from academia, government, and industry and that fosters innovation, a supportive team environment, intellectual freedom and creativity, and an emphasis on career development. The available position offers the potential for career growth and opportunities to take on more responsibilities over-time. Key Responsibilities: - Serve as an cell biologist and/or tissue bioengineer subject matter expert (emphasis on lung, liver, gastrointestinal, neural, and/or lymphoid tissue biology) for interdisciplinary teams including biologists, engineers, chemists, bioinformaticians, etc.
- Plan and execute hands-on experiments in a BSL-2 lab with Draper's novel in vitro platform technologies (microphysiological system or organs-on-chip); train and supervise junior staff.
- Lead mammalian cell and tissue culture and assay development; assist in troubleshooting experimental work in coordination with colleagues as needed.
- Analyze, report, and present experimental data to internal management, external customers, and/or for publication.
- Work across a broad spectrum of engineering and biological applications to solve our customers' most challenging needs including biodefense/biosecurity and medical countermeasure development applications.
- Multitask within a dynamic and diverse project environment and adapt to changing priorities.
- Support lab organization and maintenance as needed.
- PhD in biomedical engineering, cell biology, stem cell biology, immunology or related field, with demonstrated understanding of human cell and tissue biology and advanced in vitro cell culture platforms.
- Expertise in primary mammalian cell and tissue culture (human or animal), including complex multi-cell type co-culture, 3D cell culture/organoid biology, and/or stem cell culture.
- Experience engineering tissue with resident immune cell populations, i.e. immune-competent tissue models.
- Experience with primary-derived cell culture differentiation methodologies; phenotypic and functional characterization of tissue-specific and/or immunological cells; identification and/or understanding of key biomarkers for core tissue cell populations, and/or tissue-resident or blood-derived immune cell populations.
- Expertise applying fundamental biology knowledge to novel in vitro cell culture systems such as microphysiological systems or organs-on-chip.
- Experience with standard cell and molecular biological assays such as ELISA/Luminex, nucleic acid extraction, qPCR, immunofluorescence staining and confocal microscopy, cell proliferation/viability assays, cytotoxicity assays, flow cytometry / FACS, magnetic cell sorting.
- Ability to solve complex problems with minimal supervision, adapt to changing priorities, interface with all levels of internal management, as well as program sponsors and subcontractors
- Self-starter with excellent written and oral communication skills, laboratory organizational skills, and attention to detailPreferrable skills and experience:
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