(Senior) Bioinformatics Data Engineer, Omics Pipelines, Translational and Quantitative Sciences D... - Princeton New Jersey

Company: Genmab
Location: Princeton, New Jersey
Posted On: 11/07/2024

Job DescriptionAt Genmab, we're committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in science, we believe that being proudly unique, determined to be our best, and authentic is essential to fulfilling our purpose.The RoleThe successful candidate will contribute to the mission of the global data engineering function and be responsible for many aspects of data including creation of data-as-a-product, architecture, access, classification, standards, integration, and pipelines. Although your role will involve a diverse set of data-related responsibilities, your key focus will be on the creation of bioinformatics pipelines to process bulk and single cell genomics and transcriptomics data for the enablement and downstream interpretation of Translational and Quantitative Sciences functions, including Data Science, Translational Medicine, Precision Medicine, and Translational Research. You will have a balance of subject matter expertise in life science data, terminology and processes and technical expertise for hands-on implementation. You will be expected to create workflows to standardize and automate data, connect systems, enable tracking of data, implement triggers and data cataloging. With your experience in the Research domain, you will possess knowledge of diverse assay types such as IHC, flow cytometry, cytokine data, but specialize in genomics and transcriptomics. Your ultimate goal will be to place data at the fingertips of stakeholders and enable science to go faster. You will join an enthusiastic, agile, fast-paced and explorative global data engineering team.Responsibilities

• Design, implement and manage ETL data pipelines that process and transform vast amounts of scientific data from public, internal and partner sources into various repositories on a cloud platform (AWS)
• Incorporate bioinformatic tools and libraries to the processing pipelines for omics assays such as bulk and single cell RNASeq
• Enhance end-to-end workflows with automation that rapidly accelerate data flow with pipeline management tools such as Step Functions, Airflow, or Databricks Workflows in combination with specialized bioinformatics pipeline tools such as WDL, Nextflow, or Snakemake
• Implement and maintain bespoke databases for scientific data (RWE, in-house labs, CRO data) and consumption by analysis applications and AI products
• Innovate and advise on the latest technologies and standard methodologies in Data Engineering and Data Management, including recent advancements with GenAI, and latest bioinformatics tools, modules and techniques in RNA sequencing analysis
• Manage relationships and project coordination with external parties such as Contract Research Organizations (CRO) and vendor consultants / contractors
• Define and contribute to data engineering practices for the group, establishing shareable templates and frameworks, determining best usage of specific cloud services and tools, and working with vendors to provision cutting edge tools and technologies
• Collaborate with stakeholders to determine best-suited data enablement methods to optimize the interpretation of the data, including creating presentations and leading tutorials on data usage as appropriate
• Apply value-balanced approaches to the development of the data ecosystem and pipeline initiatives
• Proactively communicate data ecosystem and pipeline value propositions to partnering collaborators, specifically around data strategy and management practices
• Participate in GxP validation processesRequirements
  • BS/MS in Computer Science, Bioinformatics, or a related field with 5+ years of software engineering experience (8+ years for senior role) or a PhD in Computer Science, Bioinformatics or a related field and 2+ years of software engineering experience (5+ years for senior role)
  • Excellent skills and deep knowledge of ETL pipeline, automation and workflow managements tools such as Airflow, AWS Glue, AWS Step Functions, and CI/CD is a must. Strong preference specifically for AWS Step Functions and Lambda.
  • Excellent skills with bioinformatics pipeline tools and troubleshooting for quality such as Snakemake, WDL, and Nextflow. Strong preference for Nextflow.
  • Excellent skills and deep knowledge in Python, Pythonic design and object-oriented programming is a must, including common Python libraries such as pandas. Experience with R a plus
  • Excellent understanding of different bioinformatics modules and databases such as STAR, HISAT2, featureCounts, fastQC, RSeQC and Cell Ranger and how they're used on different types of genomic and transcriptomic data such as single cell transcriptomics
  • Solid understanding of modern data architectures and their implementation offerings such as Databricks' Delta Tables, Athena, Glue, Iceberg, and their applications to Lakehouse and medallion architecture.
  • Experience working with clinical data and understanding of GxP compliance and validation processes
  • Proficiency with modern software development methodologies such as Agile, source control, project management and issue tracking with JIRA
  • Proficiency with container strategies using Docker, Fargate, and ECR
  • Proficiency with AWS cloud computing services such as Lambda functions, ECS, Batch and Elastic Load Balancer and other compute frameworks such as Spark, EMR, and Databricks. Strong preference for experience with AWS Omics.For US based candidates, the proposed salary band for this position is as follows:$114,375.00---$190,625.00The actual salary offer will carefully consider a wide range of factors, including your skills, qualifications, experience, and location. Also, certain positions are eligible for additional forms of compensation, such as bonuses.About You
    • You are passionate about our purpose and genuinely care about our mission to transform the lives of patients through innovative cancer treatment
    • You bring rigor and excellence to all that you do. You are a fierce believer in our rooted-in-science approach to problem-solving
    • You are a generous collaborator who can work in teams with diverse backgrounds
    • You are determined to do and be your best and take pride in enabling the best work of others on the team
    • You are not afraid to grapple with the unknown and be innovative
    • You have experience working in a fast-growing, dynamic company (or a strong desire to)
    • You work hard and are not afraid to have a little fun while you do soLocationsGenmab leverages the effectiveness of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are designed as open, community-based spaces that work to connect employees while being immersed in our state-of-the-art laboratories. Whether you're in one of our collaboratively designed office spaces or working remotely, we thrive on connecting with each other to innovate.About GenmabGenmab is an international biotechnology company with a core purpose guiding its unstoppable team to strive towards improving the lives of patients through innovative and differentiated antibody therapeutics. For more than 20 years, its passionate, innovative and collaborative team has invented next-generation antibody technology platforms and leveraged translational research and data sciences, which has resulted in a proprietary pipeline including bispecific T-cell engagers, next-generation immune checkpoint modulators, effector function enhanced antibodies and antibody-drug conjugates. To help develop and deliver novel antibody therapies to patients, Genmab has formed 20+ strategic partnerships with biotechnology and pharmaceutical companies. By 2030, Genmab's vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO™) antibody medicines.Established in 1999, Genmab is headquartered in Copenhagen, Denmark with locations in Utrecht, the Netherlands, Princeton, New Jersey, U.S. and Tokyo, Japan. Our commitment to diversity, equity, and inclusionWe are committed to fostering workplace diversity at all levels of the company and we believe it is essential for our continued success. No applicant shall be discriminated against or treated unfairly because of their race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), national origin, age, disability, or genetic information. Learn more about our commitments on our website. Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on our website https://www.genmab.com/privacy.Please note that if you are applying for a position in the Netherlands, Genmab's policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the fixed-term employment contract. More...

          

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